The International Study to Predict Optimised Treatment Response – in Depression (iSPOT-D)
United States, New Zealand and Australia.
We know that less than 40% of people with depression respond to their first treatment with an antidepressant. There is also no way for clinicians to determine whether one antidepressant will be more beneficial than another. iSPOT-D is the largest international research study ever undertaken into Major Depressive Disorder that aims to develop a simple assessment tool to help health care professionals to prescribe each individual onto the right medication first go. Our site is one of 18 sites world-wide.
What is involved:
- Two assessment visits:
- Before taking the antidepressant medication &
- 8 weeks after starting the medication
- Follow-up calls
Your Clinician will be sent reports and asked to prescribe and titrate the medication. As this is a research project you will be randomized to one of three commonly prescribed medications (escitalopram SSRI, venlafaxine XR SNRI, and sertraline SSRI) on your first visit.
This research study is free of charge and participants are reimbursed for travel expenses and time.
- Symptom reports
- Diagnostic & severity interviews (before & after medication)
- Thought & information processing reports (before & after medication)
- Brain Scans (MRI report). (This component is only available at some sites)
Can I take part in iSPOT-D research?
To be included in this research, you MUST meet the following criteria:
|Proficient in English|
|Not currently on an antidepressant medication or willing to change medications|
|No other psychological disorder (excluding anxiety disorders)|
|No known neurological conditions that may interfere with assessments or drug treatment|
|Not currently drug or alcohol dependent|
|Not pregnant or breastfeeding|
If you answer YES for all of the above criteria, you are invited to take part in our research.
Please DO NOT enter personal information on behalf of another individual.
*Personal information collected will only be disclosed to the research team in order to contact you. Personal information will not be disclosed outside of the resaerch site(s).
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